According to Xinhua News Agency Chongqing Electric (reporter Li Hualing) internationally renowned science magazine "Nature" (Nature) recently published by the Third Military Medical University, led by original research results, revealing a new group of CD8 + T cell subclasses to clarify its inhibition of viral replication Mechanisms. This finding will help understand chronic viral infections immunity key for cure HIV, hepatitis B and other chronic viral infections provides new possibilities.
In the international academic community, Nature and Science, Cell and known as the three leading technology magazine (abbreviated CNS). The study led by Third Military Medical University since early 2013 launch, after researchers tireless research, after nearly four years of a major breakthrough.
The study on the corresponding author, Professor Ye Lilin Third Military Medical University, the previous studies have found that in acute viral infections, specific CD8 + T cells by killing infected cells secrete antiviral cytokines in order to effectively clear the virus. But in the course of chronic viral infection, virus-specific CD8 + T cells but showing the medical profession is called & ldquo; functional exhaustion & rdquo; phenomenon. & Ldquo; In this case CD8 + T cells can not identify the virus, how to reduce the number also did not like the police encountered a group of criminals, which drew fire but this can not start killing weapons. & Rdquo; he said.
Generally it believes that at this time CD8 + T cells almost completely lost the function of clearing the virus. But the study found that chronic viral infection, although CD8 + T cells appear to be & ldquo; & rdquo ;, functional depletion virus is still maintained at a relatively low level, there is no outbreak in a short time. Thus, CD8 + T cells have lost functional point of view is not convincing.
Research group eventually found, & ldquo; functional exhaustion & rdquo; of CD8 + T cells still have certain anti-virus function, and controls the replication of the virus to a large extent. It turned out that a new group of CD8 + T cells play a key role subclass, the group called CXCR5-positive CD8 + T cells. In this study, the research group also identified Id2 / E2A is to generate a signal axis of the cell subsets important regulatory factor.
It is reported that the treatment of HIV, hepatitis, cancer and other chronic diseases caused by viral infections, chemical drugs can inhibit viral replication to some extent, still can not be completely eradicated. Professor Ye Lilin pointed out: & ldquo; through certain means to increase and stabilize this type of CD8 + T cells can enhance the function of clearing the virus. This offers new possibilities for the cure of these diseases fundamentally. & Rdquo;
Professor Ye Lilin said the next step, they will use the research results to HIV and the immune therapy of tumors, to explore these two world-class medical problems and possible solutions paths.
It is understood, the researchers Tsinghua University, Fudan University and other institutions also participated in the study, Professor Qi Hai Third Military Medical University and Tsinghua University Professor Wu Yuzhang with the treatise is co-corresponding author, first author was the Third Military Medical University doctoral He then, eight years and Tsinghua University doctoral student Liu Cheng Hou Yue poetry.
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