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Chinese experts found that asthma treatment of new targets boarded the "Science" magazine cover

via:人民网     time:2018/2/9 14:02:44     readed:368

Shanghai University of Traditional Chinese Medicine Professor Yang Yongqing

Bronchial asthma is a common respiratory disease seriously affect human health, the main drug treatment is the routine corticosteroids and beta 2 receptor agonist drugs, these drugs in addition to a variety of side effects, but also very prone to resistance, can relieve symptoms and other issues, so that a new target for the treatment of asthma, asthma treatment research the new drug is currently facing a serious challenge in asthma.

Based on the clinically effective acupuncture anti-asthma treatment method, the research team headed by Professor Yang Yongqing found that acupuncture at Ovariectomy, Fengmen and Feishu can significantly improve the respiratory function and increase the activity of metallothionein-2 (MT-2) Protein content. The establishment of a mouse model of asthma proves that the protein plays a key role in the pathogenesis of asthma. Using the related research methods, it was also found that the receptor of MT-2 on the tracheal smooth muscle cells is Transgelin-2, and the receptor of the MT-2 is detected by using the methods of radioactive receptor analysis, confocal laser scanning, RNA interference, surface plasmon resonance, Gene knockout animal models and other technologies and methods were confirmed and verified. Transgelin-2 protein has also become the first new target of bronchial asthma discovered and verified by Chinese researchers.

Professor Yang Yongqing's team further cooperated with the Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Using molecular docking and virtual screening techniques, we selected 6,000 compounds that could specifically bind to the target of anti-asthma target Transgelin-2, And clinical characteristics of the asthma model and so on, validation and confirmed that "acupuncture" leading compound TSG12 mitochondrial smooth muscle function is a potential anti-asthma new drug with good clinical application prospects. The study also demonstrated that the Transgelin-2 receptor is activated by the "calcium sensitization" pathway to relax the effector mechanism of the tracheal smooth muscle.

Commenting on the journal's expert opinion is an inspiring and thought-provoking masterpiece, the editor-in-chief also commented specifically on the article entitled Tickling transgelin-2 for asthma relief, arguing that therapies that target Transgelin-2 receptors To solve the current predicament in asthma has opened up a new path. Chinese Academy of Sciences, Chinese Academy of Sciences Institute of Shanghai Institute of Materia Medica Jiang Huariang director as early as 2003 and Yang Yongqing research team set up a joint laboratory of acupuncture and Chinese medicine effect, and that from a significant clinical treatment of acupuncture methods to study the new target of disease treatment, Which can avoid the clinical failure risk of target discovery to the maximum and solve the problem of lack of clinical intervention in the current target discovery and functional verification. Professor Zhu Weiliang, professor of "Hundred Talents Program" and director of Center for Drug Discovery and Design, Shanghai Institute of Materia Medica, Chinese Academy of Sciences believes that this study can be regarded as the first target of independent intellectual property rights and discovery of new drugs in China.

Yang Yongqing research team for acupuncture regulation of disease in this complex system, "group learning" technology research, is the application of contemporary biotechnology interpretation of traditional Chinese acupuncture mechanism a powerful attempt to maintain our country in acupuncture research in the field of international leader in the first in the Acupuncture and moxibustion field of research with independent intellectual property rights has important strategic significance, at the same time to solve the major problems of contemporary life sciences to seek new breakthroughs and innovative drug development to provide new research ideas.

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