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MIT simulates neurons and muscles on the microchip for new drugs.

via:博客园     time:2018/10/11 12:08:06     readed:80

Surging news reporter Yu Hanqi

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A team from (MIT), Massachusetts Institute of Technology (MIT), reported on a 3D model of nerve and muscle tissue on a microfluidic chip on October 11 in Scientific Progress. With the help of this

Only a few.

冰桶挑战。

Ice bucket challenge. Visual Chinese data sheet

The junction between motor neurons and muscle cells, the muscle-nerve junction, is a simulation.

Roger MIT, Professor of Mechanical and Biological Engineering, 2016

They divided neurons and muscle fibers into two adjacent compartments on the chip. Neurons gradually extend their usual processes and eventually connect to muscle fibers that wrap around two flexible pillars.

These neurons have been edited by optical genetics and can stimulate muscle contraction under light control. By observing the displacement of two flexible columns, the researchers can measure the intensity of muscle contraction.

In the published results, the Kam team used human neurons and muscle cells instead. Some of these neurons are derived from induced pluripotent stem cells (iPSCs) in healthy people and some from induced pluripotent stem cells (IPSCs) in sporadic ALS patients.

The results of the experiment show that

“芯片器官”:绿色部分为渐冻症患者诱导性多能干细胞分化而成的运动神经元,紫色部分为肌肉组织。

Two weeks later, ALS motor neurons built up control of the muscles, only one fourth of the healthy neurons.

open up before one's eyes

They selected two new drugs, rapamycin (Rapaycin) and betatinib (Bosutinib)., which are still in clinical testing In

Currently, the Cam team is working with local biotechnology companies to plan to collect 1000 people

They also intend to upgrade the model itself to accommodate both more samples and other cell types in the nervous system, such as Schwann cells and microglia.

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