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GM kidney successfully transplanted to people: proven to be used in human organ transplantation

via:快科技     time:2021/12/18 10:03:35     readed:133

According to foreign media reports, the Director of Robert Middot, Director of the University of New York University, Robert Montgomery, once again launched the experiment of pig renal heterogeneous transplantation to the human body.

In October This year, Dr. Montgomery successfully killed the pig kidneys and the volunteers maintained by the ventilator through the thigh blood vessels and lasted for 54 hours.

During the test,Urine generation and creatinine levels (key indicators of kidney function) are normal, almost have the same effects with human kidney transplantation, and have not found a row.

Recently, Dr. Montgomery once again launched this surgery, which also puts a pig kidney lacking alpha-gal genes to a volunteer who relies on ventilator to maintain life.

Dr. Montgomery said thatAlthough this is only replicated again, it further proves that the genetic engineering organs can be used in patients who urgently transplant.This also laid the foundation for the future human test, although there are still many jobs that need to be done, but it is undoubtedly successful.

It is reported that the pig kidney in the test is provided by the United States Joint medical subsidiary REVIVICOR. The transgenic pig has been approved by the US Food and Drug Administration (FDA), which can be used in food and medical products.

Such transgenic pigs knock down proteases of Alpha-ga sugars on the surface of the pig cells, so that pig cells no longer express Alpha-gal sugar.

Although Alpha-gal sugar stores in many mammals, it is not common in humans, while ALPHA-GAL Syndrome (AGS) patients tend to allergies of meat.

Therefore, this kind of pig can not only make allergies, but also potential medical purposes. For example, it can be used to produce drugs similar to heparin, as well as heterogeneous organ transplantation.

科学家成功将猪肾移植到人身上 专家:证明可用于人体器官移植

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