Home > News content

Science: What are the technological breakthroughs behind people behind people?

via:新华网     time:2022/1/12 14:01:02     readed:59

Xinhua News Agency, January 11th (Reporter Feng Yuxi) Released in the 10th of the US Maryland University Medical Center to say that medical experts will transplant the heart of the gene-transformed pig into a US heart patient, which is the world's first. Human-reliented reactions are usually a problem in heterogeneous organ transplantation, why can this pig heart transplant surgery make great progress? What technological breakthroughs have been taken behind?

Many patients in the world is currently transferred by different diseases, but donated human organs cannot meet this type of demand. Senior organ transplantation research provides more choices to solve the "transplant organs", but also facing technical difficulties such as intensive viral communication, immune compatibility.

The organ tissue structure of pigs, physiological functions and sizes are similar to those of the human organs, and is considered one of the best animals of exotic organ transplant donors. However, it may be "toxicity" with endogenous reverse transcriptional viruses in the human body: pigs may have "toxic" after transplantation to the human body; pig organs may initiate immune rejection in patients.

In order to solve the shortage of transplanted organs, multi-country is trying to carry out heterogeneous transplantation with pigs, and some breakthroughs have been made in recent years. Sino-US et al. 2017 report that they use gene editing techniques to "knock out" all endogenous reverse transcriptional viruses in the pig genome, and these pigs have no risk of associated viral infections if they transplant them.

Research on immune compatibility is also progressing. Ma Yanna & Middot; Zazash 2019 reported that scientists have confirmed that three genes in pigs can cause genetic reactions in the pig, close these genes with genetic editing techniques such as CRISPER / CAS9, and may eliminate human body The immune system has been tuned from pig organs.

With these research progress, the transplant surgery carried out in the United States has achieved a new breakthrough.

According to the Medical Center of the Maryland, pigs used in transplant surgery have been genetically modified - three of them cause three genes "knockout" that caused three pigs to produce people to pig organs; another specific The gene was "knockout" to prevent excessive growth of pig heart tissue to implant the human body. In addition, researchers embed 6 associated human genes into the genome of pigs to make their organs are more susceptible to human immune systems. At the same time, the surgical team also uses anti-artisan drugs to inhibit the human immune system and prevent the organism to react.

The center said this transplant surgery first shows a genetically modified animal heart to enter the body, can play like a human heart, and the body will not immediately react to this animal heart. In the next period of time, the team will continue to observe the patient to determine if the migration technology of the heterogeneous organs can continue to play a role.

[Editor in charge: Qiu Lifang]

translate engine: Google

China IT News APP

Download China IT News APP

Please rate this news

The average score will be displayed after you score.

Post comment

Do not see clearly? Click for a new code.

User comments